Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease.
Identifieur interne : 000541 ( Main/Exploration ); précédent : 000540; suivant : 000542Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease.
Auteurs : Giuseppe Nicoletti [Italie] ; Vincenzo De Luca [Canada] ; Patrizia Tarantino [Italie] ; Monica Gagliardi [Italie] ; Grazia Iannello [Italie] ; Fabiana Novellino [Italie] ; Maurizio Morelli [Italie] ; Grazia Annesi [Italie] ; Aldo Quattrone [Italie]Source :
- Psychiatry research [ 1872-7123 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Alleles, Cognition Disorders (etiology), Cognition Disorders (genetics), Dementia (etiology), Dementia (genetics), Female, G-Protein-Coupled Receptor Kinase 5 (genetics), Genetic Association Studies, Genetic Predisposition to Disease, Haplotypes, Humans, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (genetics), Polymorphism, Single Nucleotide, Risk Factors.
- MESH :
- chemical , genetics : G-Protein-Coupled Receptor Kinase 5.
- complications : Parkinson Disease.
- etiology : Cognition Disorders, Dementia.
- genetics : Cognition Disorders, Dementia, Parkinson Disease.
- Aged, Alleles, Female, Genetic Association Studies, Genetic Predisposition to Disease, Haplotypes, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors.
Abstract
The objective of our study was to investigate the association of two single nucleotide polymorphisms (SNPs) with genetic risk of dementia. In 212 patients with Parkinson's disease (PD), we investigated two polymorphisms within the G-protein coupled receptor kinase 5 (GRK5) gene (rs2420616, rs4752293) to determine a possible risk factor for dementia. We identified two alleles most significantly present in PD patients with dementia: G and T alleles. We also identified risk haplotypes: GC, and AT. We demonstrated that the SNPs and the related haplotypes could play a central role in predisposing PD patients to cognitive impairment.
DOI: 10.1016/j.psychres.2015.11.026
PubMed: 26614013
Affiliations:
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Electronic address: g.nicoletti@unicz.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Neuroimaging Research Unit, IBFM-CNR, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="De Luca, Vincenzo" sort="De Luca, Vincenzo" uniqKey="De Luca V" first="Vincenzo" last="De Luca">Vincenzo De Luca</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychiatry, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Tarantino, Patrizia" sort="Tarantino, Patrizia" uniqKey="Tarantino P" first="Patrizia" last="Tarantino">Patrizia Tarantino</name><affiliation wicri:level="1"><nlm:affiliation>Neuroimaging Research Unit, IBFM-CNR, Catanzaro, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Neuroimaging Research Unit, IBFM-CNR, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Gagliardi, Monica" sort="Gagliardi, Monica" uniqKey="Gagliardi M" first="Monica" last="Gagliardi">Monica Gagliardi</name><affiliation wicri:level="1"><nlm:affiliation>Neuroimaging Research Unit, IBFM-CNR, Catanzaro, Italy; Institute of Neurology, University "Magna Graecia", Catanzaro, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Neuroimaging Research Unit, IBFM-CNR, Catanzaro, Italy; Institute of Neurology, University "Magna Graecia", Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Iannello, Grazia" sort="Iannello, Grazia" uniqKey="Iannello G" first="Grazia" last="Iannello">Grazia Iannello</name><affiliation wicri:level="1"><nlm:affiliation>Neuroimaging Research Unit, IBFM-CNR, Catanzaro, Italy; Institute of Neurology, University "Magna Graecia", Catanzaro, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Neuroimaging Research Unit, IBFM-CNR, Catanzaro, Italy; Institute of Neurology, University "Magna Graecia", Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Novellino, Fabiana" sort="Novellino, Fabiana" uniqKey="Novellino F" first="Fabiana" last="Novellino">Fabiana Novellino</name><affiliation wicri:level="1"><nlm:affiliation>Neuroimaging Research Unit, IBFM-CNR, Catanzaro, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Neuroimaging Research Unit, IBFM-CNR, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Neurology, University "Magna Graecia", Catanzaro, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, University "Magna Graecia", Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation wicri:level="1"><nlm:affiliation>Neuroimaging Research Unit, IBFM-CNR, Catanzaro, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Neuroimaging Research Unit, IBFM-CNR, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation wicri:level="1"><nlm:affiliation>Neuroimaging Research Unit, IBFM-CNR, Catanzaro, Italy; Institute of Neurology, University "Magna Graecia", Catanzaro, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Neuroimaging Research Unit, IBFM-CNR, Catanzaro, Italy; Institute of Neurology, University "Magna Graecia", Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author></analytic><series><title level="j">Psychiatry research</title><idno type="eISSN">1872-7123</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alleles</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (genetics)</term><term>Dementia (etiology)</term><term>Dementia (genetics)</term><term>Female</term><term>G-Protein-Coupled Receptor Kinase 5 (genetics)</term><term>Genetic Association Studies</term><term>Genetic Predisposition to Disease</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (genetics)</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>G-Protein-Coupled Receptor Kinase 5</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Dementia</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cognition Disorders</term><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Alleles</term><term>Female</term><term>Genetic Association Studies</term><term>Genetic Predisposition to Disease</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of our study was to investigate the association of two single nucleotide polymorphisms (SNPs) with genetic risk of dementia. In 212 patients with Parkinson's disease (PD), we investigated two polymorphisms within the G-protein coupled receptor kinase 5 (GRK5) gene (rs2420616, rs4752293) to determine a possible risk factor for dementia. We identified two alleles most significantly present in PD patients with dementia: G and T alleles. We also identified risk haplotypes: GC, and AT. We demonstrated that the SNPs and the related haplotypes could play a central role in predisposing PD patients to cognitive impairment.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Italie</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name></noRegion><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><name sortKey="Gagliardi, Monica" sort="Gagliardi, Monica" uniqKey="Gagliardi M" first="Monica" last="Gagliardi">Monica Gagliardi</name><name sortKey="Iannello, Grazia" sort="Iannello, Grazia" uniqKey="Iannello G" first="Grazia" last="Iannello">Grazia Iannello</name><name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name><name sortKey="Novellino, Fabiana" sort="Novellino, Fabiana" uniqKey="Novellino F" first="Fabiana" last="Novellino">Fabiana Novellino</name><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><name sortKey="Tarantino, Patrizia" sort="Tarantino, Patrizia" uniqKey="Tarantino P" first="Patrizia" last="Tarantino">Patrizia Tarantino</name></country><country name="Canada"><region name="Ontario"><name sortKey="De Luca, Vincenzo" sort="De Luca, Vincenzo" uniqKey="De Luca V" first="Vincenzo" last="De Luca">Vincenzo De Luca</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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